Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review

/Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review

Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review

By |2018-11-29T04:48:24+00:00November 17th, 2016|

Type & Status:

 Review | 4 - Paginated paper (printed)

Authors:

 Yu, Z.; Yan, B.; Gao, L.; Dong, C.; Zhong, J. D.; Ortenzio, M.; Nguyen, B.; Seong Lee, S.; Hu, X.; Liang, F.

Journal

 Current Cancer Drug Targets, 16/6 (2016), pp. 509-521

Abstract


Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.

DOI:

 n/a

Publication is not open access. Please request a reprint using the submitting author's email below
feng_liang@whu.edu.cn

Keywords: bleomycin; electrochemotherapy; liposomes; microsphere; nanoparticles; ultrasound; targeted therapy; bleomycin;