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Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST

Vytautas Magnus University

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Vileikos 8
LT-44404 Kaunas
Lithuania

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Brief presentation of the institution

Vytautas Magnus University established in 1922, during Soviet occupation in 1940 was closed, re-established in 1989. and ranked as the TOP 700 university in the world (QS World University Rankings), Vytautas Magnus University is one of the most liberal and modern academic institutions in Lithuania, boasting an exciting history, nurturing and continuing deep-rooted traditions, playing a leading role in not just Lithuanian, but also the entire Baltic and European intellectual and cultural sphere. Since the re-establishing of the University and Faculty of Natural Sciences prof. M. Venslauskas has established Biophysical research group that deals with cell and tissue behavior in the electric fields, with special focus on cell electroporation and sonoporation-mediated drug and gene delivery.

Main Electroporation related topics

The group theoretically and experimentally investigates the phenomena of cell electroporation and sonoporation aiming to apply these methods for drug and gene delivery into cells and tissues. Currently exist many drugs, however due to insufficient penetration of these drugs into cells and tissues or due the various side effects they do not reach clinics. Therefore targeted drug delivery is one of the greatest challenges in medicine that can be compared even with the new drug design. One of the most important objectives of the group is to develop electroporation and sonoporation methods and to implement them in clinics for tumor treatment. Another important aim [of the group] is to elucidate the mechanisms of cell electroporation and sonoporation and to figure out possibilities for synergic action of both methods. Moreover, aiming to apply electroporation and sonoporation for gene therapy, a considerable attention is given to elucidate the mechanism of gene electrotransfer and sonotransfer.

Main Electroporation related research techniques and equipment

Custom-made electroporator, that enables generate various combinations of high voltage, (HV, 200-1000 V), short duration (10-500 µs) and low voltage (LV, 4-200 V) long-duration (0.5-500 ms) pulses,

Sonoporator (sonitron 2000), ultrasound generator Ultrazvuk T-5, EMA, custom made sonoporation system,

Needle hydrophone HNP-1000 (ONDA),

Oscilloscope (GW instek, GDS-820C),

Cell culture incubator, vertical and horizontal flow laminars, centrifuge, mini- centrifuge, cooled centrifuges, inverted microscope;

Fluorescent microscopes, fiber-optic spectrofotometer (Aventes, AvaSpec-USB2) that enables to follow up delivery of fluorescent markers in live animals.

Tecan Genios Fluorescence, Absorbance and Luminescence Reader, Spectrofotometer DU 800 (Becman Coulter)

Research topics, techniques and equipment not related to Electroporation

Part of research is dedicated to investigation of semaphorin and calcium signaling during development of nervous system

Brief information on available facilites

Cell cultures facilities;

Bacterial culture facilities;

Animal facilities (small);

Molecular biology facilities.

Willingness to accept/host visiting researchers

Publications

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

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