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Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST

University of Buenos Aires, Faculty of Exact and Natural Sciences

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Pab. I, Ciudad Universitaria
1428 Buenos Aires
Argentina

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Brief presentation of the institution

The Laboratorio de Sistemas Complejos (LSC) (Complex Systems Lab) is part of the Computer Science Department, Faculty of Exact and Natural Sciences, from the University of Buenos Aires, Argentina. The LSC is an interdisciplinary group devoted to the study of complex systems in electrochemistry and bioelectrochemistry, life sciences, high performance computing (HPC) and Grid Computing (GC). LSC members belong and are supported by the National Research Council of Argentina (CONICET).

Main Electroporation related topics

The LSC principal directions of research include cell membrane electroporation and electrofusion and their application in biology and medicine. In particular, the LSC is focused in Electrochemotherapy (ECT), Irreversible Electroporation (IRE) and Gene Electrotransfer (GET). The main goal of the research is to elucidate fundamental aspects of electric field-tissue interaction, and thus contribute to its use in electroporation based therapies. The study requires an interdisciplinary and multiescaling approach which implies working with in vivo, in vitro and in silico modeling, and at the tissue, cellular, and cell membrane level. For this end, the LSC developed Dorsal Skinfold Chambers with fluorescent markers and intravital microscopy, Spheroids and Giant Unilamellar Vesicles and Molecular Dynamics and Continuum simulation software. In the application side, the LSC developed new electrode devices minimally invasive for internal organ treatment and is routinely engaged in ECT applications in dogs and cats in local vet clinics (more than 50 patients had been treated in 2012).

Main Electroporation related research techniques and equipment

Electroporator BTX ECM 830 Harvard Apparatus 

Footswitch for ECM 830 Harvard Apparatus

Osciloscope DSOX2012A Agilent Technologies, 2 channels, 100 MHz

Segmented memory DSOX2000-SGM Agilent Technologies.

Fluorescent Microscope Olympus BX-41 

Medium Speed Camera Casio EX–FH25, 

Workstation for high resolution image acquisition and processing.

LSC hardware and software facilities (GPGPU, COMSOL, oomph-lib, Open Foam, 

PETSc, Matlab, METIS: MPI OpenMP Grid, CUDA C/C++, CUDA Fortran).

Research topics, techniques and equipment not related to Electroporation

Since long, the LSC has been engaged in Physicochemical hydrodynamics studies of growth pattern formation in electrodeposition in thin layer cells with and without external magnetic fields. The LSC posess a lab with a full optical equipment mounted in an antivibratory table, long working distance microscope, power sources, schlieren lenses, electrochemical cells, voltage and current measurement equipment, data acquisition and image processing and pH measurement equipment.

Brief information on available facilites

Access to the university center for microscopy (confocal and electronic scanning microscopy).
Access to full biochemical lab (cell culture incubators, laminar flow, fridge, cryostat).
Access to the university biotery with full facilities for in vivo modeling.
Access to the university supercomputing facilities (Beowulf cluster with 200 nodes)

Willingness to accept/host visiting researchers

Publications

Projects:

  • Argentine/Slovenian 2008
    Project type: International
    Funding: Argentine Ministry of Science and Technology
  • ITBACyT 2013
    Project type: National
    Funding: Instituto Tecnológico Buenos Aires
  • PIP 1087 CONICET
    Project type: National
    Funding: National Research Council
  • UBACyT 2009/2013
    Project type: National
    Funding: University of Buenos Aires

Members:

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

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