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Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST

Institute of Solid State Physics, Bulgarian Academy of Sciences

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72 Tsarigradsko shosse Blvd.
1784 Sofia
Bulgaria

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Brief presentation of the institution

Since its foundation 40 years ago, the mission of the Georgi Nadjakov Institute of Solid State Physics (ISSP) at the Bulgarian Academy of Sciences has consisted in the achievement of fundamental knowledge in the condensed matter physics, optics, spectroscopy and laser physics; application of this knowledge for the creation of new materials, devices and analytical methods for micro- and nano-technologies, as well as for new approaches in the interdisciplinary fields of the physics with biology, medicine, archaeology.

The main scientific and applied achievements of the Institute are in the field of condensed matter theory, critical phenomena and phase transitions, superconductivity and superconducting materials, low temperature physics, nanophysics, liquid crystal physics, soft and living matter physics, structure and properties of crystals and amorphous materials, atom and plasma physics, high precision thermometers, integrated optics, optical fibres, optics and spectroscopy of thin films, acoustoelectric and microelectronic sensors, metal vapour lasers.

Main Electroporation related topics

Research has been initiated in the mid 70ies of the 20th century by the Sofia Liquid Crystal Group, presently Soft Matter Division of ISSP (head Alexander G. Petrov).Sofia Group was one of the first to lay the foundations of the modern theory of edge energy and pore stability in membranes under the separate or the combined action of pore forming substances (the concept of molecular asymmetry reducung edge energy), electric fields (elucidating the field dependence of edge energy and membrane tension), early stages of electroporation (hydrophobic and hydrophilic pores and field-assisted pore inversion, metastable pores)

Main references:

  • Edge energy and pore stability in bilayer lipid membranes, by A. G. Petrov, M. D. Mitov, A. Derzhanski, Advances in Liq. Cryst. Res. and Appl., Ed. L. Bata, Pergamon Press,Oxford -     Akad. Kiado, Budapest, vol. 2, p. 695 (1980).
  • The Lyotropic State of Matter: Molecular Physics and Living Matter Physics, by A.G. Petrov, Gordon & Breach Science Publishers,  L.-N.Y. (1999),Chapters 3 and 5.

Presently, theoretical and experimental studies on the physical properties of ion channels in model and native membranes are carried out; ion channels and pores induced by pore forming chemical species and electroporation, as well as mechanosensitive ion channels are studied; micropipette technique for membrane permeability measurements is developed and employed.

 

Main Electroporation related research techniques and equipment

 

  • Phase contrast and fluorescence microscope Zeiss Axiovert 100 with thermostated plate (+/- 0.1 degr. C) - temp. control 37-2 unit;Hamamatsu Image Intensifier Head C2400-80;CCD - Hamamatsu Camera Control Unit C2400-60;
  • Narishige Micropipette Puller PB-7;
  • Micromanipulator - Carl Zeiss 471845-9901;
  • Stroboscopic Illumination Unit /Xenon Flash Lamp C6096/;
  • 15 MHz Function/Arbitrary Waveform Generator - Hewlett Packard 33120A;
  • Patch-clamp Amplifier with micromanipulator - Model 2400, A-M Systems, Inc. 
  • Digital storage oscilloscope - Tektronix 1002B
  • Balance - SCALTEC SBA/SBC; 
  • Hardware and software for data acquisition and data processing from ion channels and ion pores studied by the patch clamp method.
  • Equipment for electro-manipulation on liposomes;
  • FFT Impedance Spectroscopy System.

 

Research topics, techniques and equipment not related to Electroporation

Equipment and methods for electron microscopy and electron diffraction investigations, atomic, electric and magnetic force microscopy, X-ray diffraction with topographic, diffractometric and spectrometric facilities, ellipsometric measurements, spectroscopy from VUV to IR spectral regions, time-resolved spectroscopy, EPR spectroscopy
Equipment and know-how for single crystal growth from oxide materials for laser techniques and photorefractive effect applications, techniques and technology for thin layer deposition for microelectronic, optoelectronic and acoustoelectronic sensors and laser technology, cleanroom, complex equipment for molecular beam epitaxy, equipment for synthesis and investigation of high temperature superconducting materials
Equipment for polarization measurements in mesophases and polymer liquid crystals for display techniques, equipment for stroboscopic videomicroscopy and micromanipulation of lipid membranes
Various laser systems: gas discharge metal vapour and solid state (ns and fs) lasers, oscillating in UV, visible and IR spectral range, for plasma physics applications, laser analysis and material processing, for application in nanotechnology, medicine, archaeology, ecology, etc.
High-tech experimental setup for laser cooling of atoms (~ 0.0001K)
Equipment (Physical Properties Measurement System produced by Quantum Design, USA) for studies of electrical, magnetic and thermal properties of materials, surfaces and structures
Scanning probe microscope (VEECO, Multimode, USA) for precise surface characterization at the nanoscale.
 

Brief information on available facilites

 

  • laboratory for liposome preparation
  • laboratory for patch-clamp measurements
  • laboratory for thermal fluctuation analysis and vesicle micromanipulation
  • 20-seats classroom with overhead projector
  • 100-seats conference hall with multimedia

 

 

Willingness to accept/host visiting researchers

Publications

Members:

  • Isak Bivas
    Email:

    Position: Professor
  • Denitsa Mitkova
    Email:

    Position: PhD student
  • Krasimira Antonova
    Email:

    Position: Assoc. Prof.
  • Georgi B. Hadjichristov
    Email:

    Position: Assoc. Prof.
  • Maria Dencheva-Zarkova
    Email:

    Position: Chem. Eng.
  • Yordan G. Marinov
    Email:

    Position: Assoc. Prof.
  • Alexander G. Petrov
    Email:

    Website: www.issp.bas.bg
    Position: Academician
  • Yuliya Genova
    Email:

    Position: Assist. Prof.
  • Lidia Todorova
    Email:

    Position: Assist. Prof.
  • Victoria Vitkova
    Email:

    Position: Assoc. Prof.

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

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