print small

Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU Framework Programme Horizon 2020
This website is supported by COST

Institute of Oncology Ljubljana

Tell your friend  | 

Zaloška 2
1000 Ljubljana
Slovenia

Contact email:

Visit the website.

Brief presentation of the institution

The Institute of Oncology Ljubljana is conceived as a comprehensive public institution for detection, treatment and research of cancer. As the leading institution in this domain in the country, it ensures balanced and proper development of oncology health services in Slovenia. The Department of Experimental Oncology is a division at the Institute of Oncology Ljubljana with the main goal to bridge basic and applied research, i.e. to translate advancements in preclinical studies with clinical trials. Researchers working at the Department of Experimental Oncology develop new therapeutic modalities for the treatment of cancer, test them on cell cultures, and perform preclinical studies on laboratory animals bearing experimental tumors. The personnel of the Department of Experimental Oncology are also participating as lecturers in undergraduate and postgraduate courses.

 

Main Electroporation related topics

1. Electroporation for drug/gene delivery into cells, tissues and tumors:
- studying basic electroporation-induced processes
- seeking for the new targets
- testing preclinical effectiveness

2. Potentiation of radiation response by electroporation-mediated drug/gene delivery

3. Vascular effects of electroporation on normal and tumor tissue

4. Electrochemotherapy (ECT) and gene electrotransfer (GET)
a) Veterinary medicine:
- ECT in dogs, cats and horses
- GET in dogs and cats
- combined ECT and GET in dogs, cats and horses
b) Clinical trials:
- ECT of cutaneous tumors
- GET to cutaneous tumors
- ECT of deep-seated tumors (liver metastases)

Main Electroporation related research techniques and equipment

- electroporator
- Cliniporator
- oscilloscope

- flow cytometer
- inverted microscope
- fluorescent inverted microscope
- fluorescent stereo microscope
- spectrophotometer
- spectrofluorimeter
- inhaled anesthesia delivery systems
- x-ray generator
- autoclave
- cryotome

- laminar flow chambers
- fume hood
- incubators
- water baths
- centrifuges
- ultracentrifuges
- thermomixer
- balances

Research topics, techniques and equipment not related to Electroporation

1. The use of magnetic nanotechnology for transfection of normal and tumor cells, tissues and tumors

2. Development of cell biosensor systems for determination of effects of ionizing radiation and chemical carcinogens

3. Preparation and validation of therapeutic plasmids without selection gene for antibiotic resistance

- X-ray diffractometer (access to)
- transmission electron microscope (access to)
- dynamic light scattering system (access to)
- magnetometer (access to)
- zetameter (access to)

- agarose gel electrophoresis system
- gel documentation system
- RT-PCR system

Brief information on available facilites

Laboratory for cell cultures
Laboratory for bacterial cultures
Laboratory for experimental animals
Laboratory for imaging
Laboratory for irradiation

Willingness to accept/host visiting researchers

Publications

Projects:

  • Antiangiogenic gene therapy of cancer using electroporation and magnetic nanoparticles as targeted delivery systems (2011-2014)
    Project type: National
    Funding: Slovenian Research Agency (ARRS), Slovenia
  • Development and validation of a software for numerical modeling of in vivo electroporation - in silico electroporation (2011-2014)
    Project type: National
    Funding: Slovenian Research Agency (ARRS), Slovenia
  • Preparation and validation of therapeutic plasmids without selection gene for antibiotic resistance for cancer gene therapy using inducible and tissue-specific promoter (2011-2014)
    Project type: National
    Funding: Slovenian Research Agency (ARRS), Slovenia
  • Synthesis, characterisation and use of novel ruthenium compounds in electrochemotherapy of tumors (2011-2014)
    Project type: National
    Funding: Slovenian Research Agency (ARRS), Slovenia
  • COST TD1104: European network for development of electroporation-based technologies and treatments (EP4Bio2Med) (2011-2015)
    Project type: International
    Funding: European Commission, Brussels, Belgium
  • French-Slovenian European Associated Laboratory: Pulsed Electric Fields Applications in Biology and Medicine - LEA EBAM (2011-2014)
    Project type: International
    Funding: National Centre of Scientific Research (CNRS), France; University of Ljubljana, Slovenia; Institute of Oncology, Ljubljana, Slovenia
  • New lipid model systems for determination of electroporation basic mechanisms (2011-2014)
    Project type: National
    Funding: Slovenian Research Agency (ARRS), Slovenia

Members:

  • Tanja Blagus
    Email:

    Position: Researcher
  • Erik Brecelj, PhD
    Email:

    Position: Surgeon
  • Andreja Brožič
    Email:

    Position: PhD student
  • Maja Čemažar, PhD
    Email:

    Position: Professor
  • Tanja Dolinšek
    Email:

    Position: PhD student
  • Ibrahim Edhemović, MSc
    Email:

    Position: Surgeon
  • Gorana Gašljević, PhD
    Email:

    Position: Pathologist
  • Urška Kamenšek, PhD
    Email:

    Position: Researcher
  • Simona Kranjc, PhD
    Email:

    Position: Researcher
  • Boštjan Markelc
    Email:

    Position: PhD student
  • Maja Marolt Mušič, PhD
    Email:

    Position: Professor
  • Aleš Sedlar
    Email:

    Position: PhD student
  • Gregor Serša, PhD
    Email:

    Position: Professor
  • Marko Snoj, PhD
    Email:

    Position: Professor
  • Monika Štimac
    Email:

    Position: PhD student
  • Vesna Todorović, PhD
    Email:

    Position: Researcher

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

Related sites: