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Participating Countries:

Algeria

Argentina

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Austria

Belgium

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France

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Morocco

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COST is supported by the EU Framework Programme Horizon 2020
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Inria

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200 rue de la Vieille Tour
33405 Talence
France

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Brief presentation of the institution

 

Public science and technology institution established in 1967, Inria is is the only public research body fully dedicated to computational sciences. Combining computer sciences with mathematics, Inria’s 3,449 researchers strive to invent the digital technologies of the future.

Educated at leading international universities, they creatively integrate basic research with applied research and dedicate themselves to solving real problems, collaborating with the main players in public and private research in France and abroad and transferring the fruits of their work to innovative companies. The researchers at Inria published over 4,500 articles in 2013. They are behind over 270 active patents and 110 start-ups. In 2013, Inria’s budget came to 235 million euros, 25% of which represented its own resources.

 

Main Electroporation related topics

The electroporation modeling is addressed thanks to two-way links between the numerical simulations and the experiments: the experimental results providing preliminary results to the modeling, which then will highlight a priori the main phenomena of the experiments. The fitting of the model based on PDEs is the key point of the project. This will be performed by a data assimilation procedure well known by the INRIA team MC2. 
At the cell scale, it is proposed to develop new electrical cell PDEs models that describe simultaneously the electropermeabilization by micropulses, and the electrophysiological changes of the cell during the process (cell swelling, ions fluxes in the cell...). Moreover a theoretical asymptotic analysis will be performed to study the electropermeabilization of closely touching cells, while homogenization of single cell models will help in the understanding of the electroporation of cell suspension solution. From the experimental point of view, new device manufacturing to simultaneously electroporate vesicles and quantify this electroporation will be performed. These experiments will highlight the specificity of cell electroporation, when compared to the simplest experimental cell model that is liposome. 
At the tissue scale, Inria aims at providing a non-linear tissue conductivity modeling, with parameters that will be fitted with the experiments on potatoes, and rat liver, through data assimilation techniques based on proper orthogonal decomposition developed by MC2. Here again, both numerical and experimental influences of the pulse properties on the tissue electroporation will be investigated.

Main Electroporation related research techniques and equipment

Numerical simulations  are carried out using the PLAFRIM experimental testbed, being developed under the Inria PlaFRIM development action with support from LABRI and IMB and other entities: Conseil Régional d’Aquitaine, FeDER, Université de Bordeaux and CNRS (see https://plafrim.bordeaux.inria.fr/).

Research topics, techniques and equipment not related to Electroporation

Brief information on available facilites

Willingness to accept/host visiting researchers

Publications

Projects:

  • INTCELL
    Project type: National
    Funding: ANR
  • MEMOVE
    Project type: National
    Funding: ANR

Members:

  • Thierry Colin
    Email:

    Position: Professor
  • Michael Leguebe
    Email:

    Position: PhD student
  • Clair Poignard
    Email:

    Website: http://www.math.u-bordeaux1.fr/~cpoignar/
    Position: Researcher
  • Olivier Saut
    Email:

    Position: Researcher
  • Lisl Weynans
    Email:

    Position: Professor
Keywords: cancer cells    modelling   

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

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